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Univariate and multivariate analysis were performed using Prism software (GraphPad, La Jolla, CA).

Univariate and multivariate analysis were performed using the Cox proportional hazard regression model.

Univariate and multivariate analysis were performed using the Cox proportional hazards model.

Univariate and multivariate analysis were performed using the Stepwise Cox proportional hazard regression model.

Uni- and multivariate analysis were performed using log transformed and auto-scaled data.

Univariate and multivariate analysis were performed using the log-rank (Mantel Cox) test and the Cox proportional hazard models, respectively.

Multivariate analysis was performed using logistic and linear regression.

Kaplan-Meier and log-rank tests were used to assess survival; multivariate analysis was performed using Cox proportional hazards.

Multivariate analysis was performed using logistic regression.The cohort included 142 patients with ES and toxicity data.

The multivariate analysis was performed using as variables the constituents with content above than 5%.

For main outcome, a multivariate analysis was performed using linear regression.