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Mice were euthanized at varying time points and heart and multiple other organs harvested for confocal microscopy.
The well-characterized cell penetrating peptides, like TAT from HIV coat protein, homopolymers of arginine or lysine, are not cell specific and transduce hepatocytes and multiple other organs in addition to the heart.
While TLR4 has received much attention for its deleterious roles in I/R injury of heart and multiple other organs, such as liver [29], lung [30], kidney [31], and brain [32], accumulating evidence indicates that TLR4 may suppress the proliferation, survival, cytokine production, differentiation and immunomodulatory activity of MSC and other progenitors.
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In addition, adipose tissue can exert both endocrine and immune effects on multiple other organs through the release of adipocytokines [ 3], which are suspected to contribute to the pathogenesis of several inflammatory conditions, including rheumatoid arthritis (RA) [ 4].
These mice also develop autoimmune inflammatory disease in multiple other organs including the lungs and intestine [51].
Similar results were observed for tumors in multiple other organs including the ovary (not shown) and bone marrow (Figure 4).
The findings to date also suggest that alcohol's epigenetic effects on the gastrointestinal tract and liver may contribute to additional pathophysiological responses to alcohol in multiple other organs.
In addition, pSS may affect multiple other organs resulting in systemic manifestations.
111 Patients with advanced disease (stage IIB IVB) may have disseminated disease into lymph nodes and other organs, and may exhibit multiple immune derangements necessitating systemic therapy.
Epithelial cancers with multiple foci of other organs, such as multiple bladder tumors, frequently occur synchronously and/or metachronously.
Representative sections were taken from multiple areas of the brain and all other organs.
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