Gains at 2p23.3, 12p11.22-p11.1 and 19q12-q13.11 were identified more recurrently in sporadic cases, with the latter containing the CCNE1 gene that was also amplified in these tumours.
Among the 80 gene sets, the top most conserved gene sets are related to cardiovascular diseases, Diabetes Mellitus type 2 and Aging; moreover, the MeSH classes, used to catalogue the diseases [ 49], that occur more recurrently are Nervous System Diseases and Cardiovascular Diseases (respectively the 61 and 50%% of the totality of the terms).
We anticipate this network evolving considerably as more recurrently somatically mutated CIN cancer genes are discovered by large-scale tumor-genome sequencing efforts.
Among the alterations more recurrently found in BRCA1 tumours compared with sporadic cases were losses at 4q32.3-q34.1, 6q22.33-q26 or 12q21.2-q23.2 while gains at 6p12-p11, 10p14-p11 and 10q22 were found to be more frequent in BRCAX tumours (compared with BRCA1 cases; Figure 1A and IV).
The formation of amyloid-like aggregates has been recurrently observed in animal cells [1], [29], described in fungi [9] and more recently in bacteria [24], [30].
It is a recurrent – and recurrently urgent – theme in English football.
Poor control is associated with complex multiple surgical resections, long delay between initial resection and CK therapy, and recurrently aggressive disease uncontrolled by prior radiation.
Isolates were analysed using a PCR-fingerprinting method and the dominant and recurrently identified yeast strain was characterised.
The two discourses i.e. ideas about collectivity versus those about the individual coexisted within individual participants' accounts, with the latter being more frequently and recurrently drawn upon to attribute responsibility for problems of quality.
In this current climate of diplomacy, attention is turning to another international standard, enshrined in humanitarian law, and yet recurrently breached in the Syrian crisis – the access to humanitarian relief and safe access to healthcare.
Episodes of coordination either span the entire trial or are established and lost recurrently over its course.
