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The identification of pathways and molecules that support the properties of CSCs may lead to the development of CSC-targeting therapeutic strategies that improve the efficacy of cancer treatment.
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There is evidence of the natural occurrence of the recombination between the helper begomovirus genomes and their betasatellite molecules that supports this hypothesis [ 18, 66].
In chapter 4 we develop a conceptual algebra of molecules that supports search for chemical analog relationships with flexible abstraction over their molecular contexts.
Cholinergic cells with functioning primary cilia respond by secreting a molecule that supports dopaminergic cells' health, and without which they become death-prone.
For example, alcohol exposure augments HCV replication by altering the levels of a molecule that supports HCV replication (i.e., microRNA-122) in liver cells (i.e., hepatocytes) (Hou et al. 2013).
Thus glutamate and BDNF may be molecules that support neuron OLG interactions in the cortex.
As for elastin, the stretchy molecules that help support the skin, ultraviolet rays cause direct damage.
Molecularly, the tight interaction between inflammation and bone/cartilage loss in RA is explained by the production of enzymes such as aggrecanases and matrix metalloproteinases, which degrade articular cartilage and bone as well as molecules that support the differentiation of osteoclasts [ 7].
The computable descriptions of molecules that support search and QSAR are a key area of innovation in chemoinformatics, and the recent success of deep and shallow learning architectures in other fields has sparked interest in representation learning.
Other targets of mAbs include antagonists of soluble molecules that support myeloma growth such as interleukin (IL -6 [ 19] and vascular endothelIL -6rowth factor (VEGF) [ 20].
Here we took a systematic approach to identify small molecules that support self-renewal of naive human ESCs based on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state pluripotency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com