In vitro studies revealed that the loss of normal cell cycle control in hormone-dependent breast cancer cells can result from treatment with xenoestrogens as indicated by increased cell proliferation and modulation of estrogen-sensitive molecular parameters [ 8, 9].
In this review, we focused on the beneficial effects of green tea and its constituents in the cancer prevention and treatment and its impact on modulation of molecular pathways.
Through this route, these fatty acids may induce alterations of the cell oxidative status and modulation of oxidative stress-dependent molecular pathways related to cell proliferation, apoptosis, or inflammation.
Overall, these data suggest that the selective pressure acting on STING and RNase L is mainly related to the modulation of molecular recognition and, possibly, to the escape from viral inhibitors.
The aim of this study was to evaluate, the existence of a signature of differentially expressed microRNAs (miRNAs) during osteogenic differentiation of bone marrow MSCs from OA and healthy donors and to describe their possible implication in joint regeneration through modulation of molecular mechanisms involved in homeostatic control in OA pathophysiology.
Protein based polymers provide an exciting and complex landscape for tunable natural biomaterials through modulation of molecular level interactions.
Novel lncRNAs are now being uncovered at an increasing rate, with molecular functions that include recruitment of histone-modifying complexes to chromatin [e.g. HOTAIR and HOTTIP (Rinn et al., 2007; Wang et al., 2011)] and modulation of transcription and splicing by molecular interaction with relevant factors [e.g. GAS5 and MALAT1 (Bernard et al., 2010; Kino et al., 2010)].
Modulation of molecular markers such as pMEK1/2, pC-Raf, pMKK4, pmTOR and pAKT suggested reactivation of the MAPK pathway as well as activation of the compensatory PI3K pathway, respectively.
Additionally, CNTs can also be designed as new tools for modulation of molecular functions, by directly affecting various biological processes or by interaction with bioactive molecules.
Pharmacological modulation of molecular chaperones is a promising therapeutic strategy in several conformational diseases [ 82].
