The phrase "and modulation of lymphocyte" is correct and usable in written English.
It can be used in contexts related to immunology, biology, or medical research when discussing the regulation or adjustment of lymphocyte activity.
Example: "The study focused on the role of cytokines in the activation and modulation of lymphocyte responses during an immune reaction."
Alternatives: "and regulation of lymphocytes" or "and adjustment of lymphocyte activity."
These effects include alteration – usually inactivation – by enzymatic cleavage of several chemokines such as substance P and RANTES, and modulation of T lymphocyte proliferation via interaction with the CD3 signaling pathway and binding of adenosine deaminase (ADA) [2], [3].
GA can activate certain immune functions, such as IFN production, augmentation of NK cell activity, and modulation of the growth response of lymphocytes via augmentation of IL-2 production [ 70].
This effort led to the discovery of BAF312 (1- 4-{1-[(E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic E -4-cyclohexyl-3-trifluoromethylbenzyloxyimino]-ethyl}-2-ethylbenzyl -azetidine-3-carboxylic
Twelve-week interval appears to be sufficiently long to induce significant shifts in CD4 counts, suggesting that these measurements help monitoring modulation of lymphocyte trafficking and cell redistribution in MS patients, temporarily discontinuing natalizumab therapy.
Observed significant shifts in CD4 counts – dramatically increasing from the baseline while on treatment and decreasing back to the baseline level off treatment, then rising in a similar manner on natalizumab reinitiation, suggest that these measurements may aid in monitoring modulation of lymphocyte trafficking and cell redistribution.
Modulation of lymphocyte migration through targeting of SELL and CCR7 is proposed to facilitate HIV-1 immune avoidance (Ramirez et al., 2014; Vassena et al., 2015), and downregulation of NTB-A protects HIV-infected cells from NK cell lysis (Shah et al., 2010).
Based on n-3 PUFAs effects on lymphocytes and modulation of inflammation, n-3 PUFAs, especially EPA or DHA, are shown to have multiple antigastric-tumor actions.
Thus, the modulation of lymphocyte homeostasis through the functional manipulation of CCL17 harbours opportunities for the design and application of novel therapeutics for the treatment of atherosclerotic vascular disease.
The selective inhibition of chemokine chemokine and chemokine GAG interactions, the use of newly identified chemokine-inhibiting proteins from ticks or viruses, or the modulation of lymphocyte homeostasis, for example by the blockade of CCL17 might open fresh perspectives for the therapeutic targeting of the chemokine system in atherosclerosis and other inflammatory diseases.
Interferon α exerts biological activities by binding to cell membranes receptors, initiating numerous cellular events, including upregulation of Th1 cells and modulation of immunological activities of macrophages and lymphocytes [ 25].
