The phrase "and modulation of a" is correct and usable in written English.
It can be used in contexts discussing changes or variations in a particular subject, often in technical or scientific discussions.
Example: "The study focuses on the effects of temperature and modulation of a signal on the overall performance of the system."
Alternatives: "and adjustment of a" or "and variation of a".
Our previous studies demonstrated a central role for the Sp4 gene in hippocampal development and modulation of a variety of behaviors relevant to human psychiatric disorders [4], [5].
4/5 adenocarcinoma cell lines failed to cell cycle arrest, down-regulate c-Myc or induce p21 in response to TGFβ, and modulation of a Smad3/4 specific promoter was inhibited.
These candidate structures provide an excellent starting point for the subsequent characterization and modulation of a peptide-mediated interaction: the atomic details of the interaction are revealed, and further refinement with the FlexPepDock refinement protocol described previously [26] can identify peptide residues that contribute significantly to binding affinity and specificity.
Binding of the autoantibodies has been shown to trigger a cascade of intracellular events that may contribute to the pathogenesis of PV, including phosphorylation of Dsg3 and its depletion from desmosomes, induction of apoptosis and modulation of a series of signalling molecules, such as Pg, PKC, p38 MAPK, heat shock protein p27, Src and c-Myc [19] [28].
Based on the data we present here, we conclude that mutation of the S1/S2 locus and modulation of a furin recognition site normally present in the S gene of FECVs is a critical contributing factor for development of FIP.
A number of modes of transcription factor interplay are evident from this data; factors binding early and acting as pioneers for the lineage-specifying proteins, antagonism expressed as mutually exclusive binding to the same site, synergism between factors, competition for a shared co-factor, redistribution of one factor by another and modulation of a regulators activity by another.
Previously, A- fibers had not been thought to possess the inherent plasticity of C- fibers [50], [55], [56] and modulation of A- fiber sensitivity was assumed to be wholly contingent upon central sensitization established by activation of C- fibers [36], [57].
[Ca2+]n is involved in the regulation of many events in the nucleus, such as gene expression, DNA replication, DNA repair, chromatin fragmentation in apoptosis, and modulation of an intranuclear contractile system.
ULK3 regulates the timing of abscission through phosphorylation and modulation of function of a member of the ESCRT complex protein IST1.
Here we describe the effects of CA-Akt on the suppression of anoikis and modulation of chemosensitivity towards a panel of chemotherapeutic agents currently used in the clinic.
Another potential mechanistic model is the plausible reduction in TAG synthesis through interaction and modulation of lipin 1, a PA phosphatase, by the C-terminus of seipin [ 66].
