High investment costs and modifications over time make evaluation of novel radiotherapy technologies in clinical trials more complex.
One of the defining features of human societies is the sophistication in social information transmission, resulting in the accumulation of behavioural traditions and its adaptive modification over time (Tomasello, Carpenter, Call, Behne, & Moll, 2005).
In science, theories are constantly under scrutiny, re-evaluation, and synthesis, leading to modification over time (or at least they should be).
Factors independently associated with cART modification during the first year of treatment were female gender, CDC stage C, year of guideline publication (with a tendency toward less treatment modification over time), and a treatment that did not follow the "what-to-start" guidelines.
Cancer stem cells may originate by malignant transformation of normal stem cells that have accumulated genetic and epigenetic modifications over time (Smalley and Ashworth, 2003; Dean et al, 2005; Visvader and Lindeman, 2008).
In particular it has become clear that the different regimes of activities undergone by nerve cells, neural assemblies and behavioural patterns, the linkage between them, and their modifications over time, cannot be fully understood in the context of even integrative physiology, without using these new techniques.
(2) The faces of roadcuts and quarries are anthropomorphic landforms of relatively well-known age and original form, two qualities that provide opportunities for discussing erosional modification over time.
Analysis of clearance modification over time was performed separately for predominantly convective and predominantly diffusive treatments.
Analysis of clearance modification over time did not show significant modifications of urea, creatinine and β2m clearance in the first 48 hours during both treatments.
It is notable in this respect that the oldest sample (Napatan) had the most such mutations and samples from the most recent strata (Islamic) had none, again consistent with base modification over time.
