Gordon, for example, notes that rapamycin has well-known and relatively modest side effects and has been tested in many children already, so she and the others running the current progeria clinical trial are "seriously considering" whether to start giving an oral derivative of rapamycin to the children.
The combination yielded a high response rate, with modest side effects.
In China, traditional Chinese herbs with modest side effects demonstrate potent efficacy to cholestasis [ 5- 7].
The modest side-effects, ease of administration and reversibility make this approach to therapy very attractive.
Despite the recent approval of several new therapeutic agents for CRPC, their overall survival effects still remain modest and their side effects are often not suitable for the treatment of elderly patients.
According to Dr Steve Harris, Circassia's CEO, current treatments are suboptimal: "Efficacy is relatively modest, and the side effects are significant, because you are delivering the very thing people are allergic to," he said, referring to the injections.
However, benefits in terms of prolonged survival and symptom relief are modest, whereas side effects are common, even when carboplatin is chosen over cisplatin for its favourable toxicity profile (Azzoli et al, 2009; Goffin et al, 2010).
Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms.
Given the modest effect and common side effects, the role for intrathecal adenosine as a sole agent for the treatment of neuropathic pain may be limited.
Unfortunately, the currently available therapies designed to improve cognition (i.e., for AD and other forms of dementia) are limited by modest efficacy and adverse side effects, and their effects on cognitive function are not sustained over time.
