The phrase "and make a substantial" is correct and usable in written English.
It can be used when discussing the act of creating or contributing something significant or considerable in various contexts, such as business, research, or personal development.
Example: "Our goal is to innovate and make a substantial impact on the industry with our new product."
Alternatives: "and create a significant" or "and have a considerable".
But many Western entrepreneurs see solar power in Africa as a chance to reach a large market and make a substantial profit.
The companies highlighted here are recognised not only for their innovations, but also their ability to bring these solutions to scale and make a substantial impact over the next five to 10 years.
Because if you make realistic estimates both of future spending and of the costs of Mr. Bush's proposed tax cut (which will end up being at least $2 trillion, and probably considerably more), it becomes clear that he will use up all of the Medicare surplus and make a substantial dent in the Social Security surplus too.
"It is nothing more complicated than the defendant wanted to cut his overhead costs and make a substantial profit," James R. Wilson, one of the assistant United States attorneys who prosecuted the case, told the jury in closing arguments last month.
For the fairly large size matrices being inverted, these optimizations matter and make a substantial difference to results obtained. .
In addition to VEGF, other proangiogenic factors including platelet-derived growth factor (PDGF), hepatoctye growth factor (HGF), basic fibroblast growth factor (bFGF), and angiopoietin-2 (are2) alsoalso elevated in the HCC plasma and make a substantial contribution to HCC angiogenesis (Semela and Dufour, 2004; Zhu et al., 2011).
"Nothing is going on until they get more realistic," Levine said, adding: "We have made a substantial and competitive offer.
"We have now taken a very important step and made a substantial investment in the diamond business," Mr. Oppenheimer said.
He said the company had apologized to the reporters and made "a substantial settlement offer" to the reporters, their relatives and charities of their choice.
Mr. Zetsche said the pay deal was "certainly in the interests of companies and workers and makes a substantial contribution to job security".
