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The phrase "and major differences between" is correct and usable in written English.
It can be used when discussing distinctions or contrasts between two or more subjects or entities.
Example: "The study highlights the similarities and major differences between the two species."
Alternatives: "and significant differences between" or "and key differences between".
Exact(3)
On Wednesday came the first signs that the talks were stalling and major differences between rich and poor countries were emerging.
Results point towards the high social value of urban woods providing that they meet specific requirements and raise some fundamental issues regarding the location, size and structure of urban woodlands for everyday public use, the relationship between the communities and the woodlands that serve them and major differences between professional and public attitudes to woodlands.
A frequent occurrence of resistance to several antimicrobial agents was observed and major differences between countries are apparent.
Similar(57)
This narrative progress report summarises the special features of improvement that are reflected in SQUIRE, and describes major differences between SQUIRE and the initial draft guidelines.
Read on for more from the producers, including their strategies for solving mysteries, how dark the show will get and the major differences between the series and the book.
Therefore, we analysed the localisation of integrin-βPS, and found no major differences between foscrb and foscrb Y10A embryos.
A general comparison between the identified metabolites in roots and shoots revealed major differences between the two tissue types.
Mr. McDonald said taxes and education would be the major differences between him and his rival.
Again, PAGE analysis (fig. 2, lanes D24h and V24h) did not reveal any major differences between dorsal and ventral shells.
There are major differences between guidelines and SPCs and neither should be referred to in isolation.
And I have noticed some major differences between apartment hunting New York and Paris.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com