The overall low number of SSRs in the H. irregulare genome, the clear dominance of trinucleotides in both the 5'UTR and within 50 bp upstream 5'UTR, and the low representation of dinucleotides within 50 bp upstream 5'UTRs suggest a history of negative selection towards those SSRs (dinucleotides) that are more likely to disrupt the functions played by these regions.
Fortunately, several characteristics of the new types of sequencing data, specifically increased depth of coverage and low representation biases in the sequencing libraries lend themselves well for finishing analysis.
Depending on the applied endonuclease, the obtained RRL contains hundreds of thousands of fragments within the optimum size range of the sequencing platform, equally distributed over the genome and with a low representation of repetitive elements.
On the other hand, PILER suffers from certain limitations including the inability to recognize TE families with few members and a relatively low representation of NLTRs in its output file which has been previously recognized (72) with a concomitant higher representation of Class II and LTRs.
The validity of the absolute value of the IBI scores is uncertain because of differences in sample collection and processing, and because of the low representation of nonperennial streams in the calibration set used to develop the IBI (Rehn and others 2005).
As a result, the planning of the participatory process did not incorporate social equity and led to a low representation of the interests of marginalized groups.
Our analysis suggests that some topological properties of the yeast interactome can also be biased due to the over-representation of proteins expressed in higher levels, which are often essential proteins, and to the parallel low representation of membrane PPIs.
The study was conducted predominately in high-income countries (i.e. United States and western Europe) and had requirements for frequent visits, which resulted in a relatively low representation of women and nonwhite participants.
The demographics of our student sample show low representation of black and Hispanic/Latino(a) students and higher representation of Asian students, with the highest representation being white students (Table 1).
Conversely, the leaf and stem libraries showed a low representation of ESTs homologous to stress related sequences, which barely reached 1%.
