Sentence examples for and lifespan in a from inspiring English sources

On the other hand, exercise increases energy expenditure and affect morbidity and lifespan in a similar way than CR on morbidity and lifespan [5], [6].

In contrast, CaEDTA exposure significantly increased healthspan and lifespan in a concentration-dependent manner, independently of the well-studied lifespan modulator DAF-16 (Suppl. Fig 2B).

Moreover, deletion of phb-1 or phb-2 (coding for mitochondrial prohibitins) has been found to influence ATP levels, animal fat content, mitochondrial proliferation and lifespan in a genetic background- and age-specific manner [ 30].

CR has been shown to slow down the aging process and increase health- and lifespan in a variety of models tested (Austad, 1989, 2012; Bishop & Guarente, 2007; Jiang et al, 2000; Lakowski & Hekimi, 1998; Mair et al, 2003; Weindruch & Walford, 1982).

Therefore, the recent publication in AGING from investigators around H. Osiewacz in Frankfurt [ 36] is therefore very important, assessing the relevance of the glyoxalase pathway for growth and lifespan in a model organism that has been very well characterized for more than 50 years within the field of healthy aging organism research, namely the fungus Podospora anserina [ 37].

The loss of Atm and Sod1 did not show any interaction with regard to the overall cellular metabolism and survival in mice [ 65], indicating that Sod1 regulates organ metabolism and lifespan in an Atm-independent manner.

Furthermore, antioxidants have also been shown to suppress cancer incidences, inhibit immunodeficiency and extend lifespan in A-T mice, in addition to neurological deficits [73], [78] [81].

In this study, the effect of SRT2104 supplementation on health and lifespan in mice on a standard diet was investigated.

However, the question remains if ad libitum feeding is more an obesity model than a normal feeding state in primates, implying that caloric restriction would 'normalize' extra food intake in primates rather than further improving health and lifespan in primates with a normal food intake.

Although the fat body-specific dFOXO upregulation increases stress resistance and lifespan in flies [ 23, 24], a heart-specific dFOXO upregulation could not be tested in stress resistance due to semi-lethality in our genetic background (data not shown), further implicating that the heart-specific Rpd3 exclusively contributes to the enhanced stress resistance.

CR (calorie restriction) has been shown to delay the onset of several age-related diseases and extend mean and maximum lifespan in a variety of species [ 1].