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It was the impetus for the Indian Removal Act (1830) and led to the Trail of Tears.
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Deglycosylation of TRAIL-R1 and TRAIL-R2 led to the diminished amounts of FADD and procaspase-8 at the TRAIL DISC, however, the effects were more drastic than upon deglycosylation of CD95 [24].
Alternative splicing of the TRAIL pre-mRNA led to the synthesis of two isoforms that were designated TRAIL-β and TRAIL-γ [ 35].
A path off the trail led to the heart of the colony.
The ability of TRAIL to selectively trigger apoptosis in cancer cells has led to the clinical development of recombinant TRAIL and TRAIL-receptor agonists as anticancer therapy.
This led to the team often trailing opponents in time of possession.
Yet another trail led to the forest at the foot of the far dune.
A trail of blood led to the garbage can from the abandoned house.
Inside, Wade and her friends followed a trail of graffitied clues that led to the cyclotron.
The necessary GT bases of SD sites for splicing processes exist also at the exon intron boundaries of exons 2 and 3. Taken together, these data indicate that post-transcriptional processing of the TRAIL-pre-mRNA leads to the generation of three alternative splice products, i.e., TRAIL- α, TRAIL- β and TRAIL- γ.
The long trail of hard evidence leads to the reward of eventual truth.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com