The phrase "and least side effects" is not correct in English.
It seems to be a truncated version of a phrase that should likely be "with the least side effects" or "and the least side effects."
Example: "This medication is effective and has the least side effects compared to others on the market."
Alternatives: "with minimal side effects" or "with the fewest side effects."
This review is a short introduction of chemotherapeutic engineering to chemical engineers, biomedical engineers, other engineers, clinical oncologists, and pharmaceutical scientists, who are interested in developing new dosage forms of drugs for chemotherapy of cancer and other diseases with the best efficacy and the least side effects.
Chemotherapeutic engineering is emerging to help solving the problems in chemotherapy and to eventually develop an ideal way to conduct chemotherapy with the best efficacy and the least side effects.
The balanced crystalloid infusion RA could stabilize micro- and macrohemodynamic, had least side effects and all animals survived when used in septic rats.
The ultimate goals of the method are to treat the patients with least side effects and to become applicable to a larger number of patients.
We should use the drug that has demonstrated the best positive impact on patients' outcome in large randomized controlled trials, the least side effects, and the best price'.
Because leishmaniasis manifestations require different management (see next paragraph), it is important to know which species is involved for the best treatment outcome, with the least side effects and late complications [ 68, 69].
There has been an ongoing quest for methods of therapeutic cooling that reduce temperature rapidly, are portable and easily instigated and/or have the least side effects.
The new guidelines also call for universal use of the simplest, most effective treatment with the least side effects: a once-daily pill containing three drugs — tenofovir, efavirenz and either lamivudine or emtricitabine.
