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Discover LudwigThe phrase "and leading cause" is correct and usable in written English.
It can be used when discussing a primary factor or reason contributing to a particular outcome or situation, often in health or social contexts.
Example: "Smoking is a leading cause of lung cancer and other respiratory diseases."
Alternatives: "and primary factor" or "and main contributor".
Exact(23)
A severe complication of diabetes and leading cause of preventable blindness is diabetic peripheral neuropathy (DPN).
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers.
Prostate cancer (PCa) is the most frequently diagnosed non-cutaneous malignancy and leading cause of cancer mortality in men.
As the lung matures in a hypoxic environment in utero, postnatal (relative) hyperoxia represents a potent stressors to the immature lung and leading cause of BPD [2].
Chronic pelvic pain could also be a sign of polycystic ovarian syndrome ― a hormonal disorder and leading cause of infertility that often begins after puberty but can occur in one's later teens or early adulthood.
We still have work to do, however, to reduce the consequences of addiction -- overdose (especially from prescription drugs, today's fastest growing drug problem and leading cause of accidental death in this country), HIV/AIDS, drug crime, etc. -- but that is a problem of will, not of want for effective strategies.
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Kevin Seldon is a writer, creator, and leading cause-marketing consultant.
DM is one of the world's major chronic diseases and leading causes of death.
The selection was based on national priorities and leading causes of death.
Colorectal cancer remains one of the most diagnosed and leading causes of cancer-related deaths worldwide.
S. aureus is a bacterial pathogen distributed worldwide and a leading cause of morbidity and mortality.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com