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The phrase "and large variation in" is correct and usable in written English.
It can be used when discussing differences or discrepancies in a particular context, such as data, results, or characteristics.
Example: "The study revealed significant findings, including a large variation in the participants' responses."
Alternatives: "and considerable variation in" or "and significant variation in".
Exact(16)
There was a significant and large variation in correlations across studies, Q (28) = 183.22, p < .01, I2 = 84.72.
There was a significant and large variation in correlations between studies, Q (27) = 275.83, p < .01, I2 = 90.21.
There was significant and large variation in correlations across studies, Q (13) = 63.18, p < .01, I2 = 77.84.
Nonetheless we believe the frequent and large variation in patches is not a good scenario for species.
Moreover, anisotropic and isotropic dry etching of silicon will result in rough silicon surface and large variation in airgap between HfO2 grating and silicon beneath HfO2 grating region, which will degrade the optical performance.
A two-dimensional stochastic problem with moderate and large variation in the random porosity field is examined and the results are compared with Monte-Carlo and sparse grid (Smolyak) collocation approaches.
Similar(44)
In coupled problems one often encounters multiscale differences (in space) and large variations in dynamics in time-domain: multirate effects [17].
In contrast, electric field-induced thermal effects are also important in the case of the NF devices, and large variations in switching occur.
Test results with multi-colored query objects from man-made and natural domains show that FOCUS is quite effective in handling interfering backgrounds and large variations in scale.
This framework is a two non-local parameter framework that takes into consideration large variations in the plastic strain tensor and large variations in the plasticity history variable; the equivalent (effective) plastic strain.
The model features coordinate transformations that efficiently incorporate moderately irregular basin geometries and large variations in bottom topography, and permits the inclusion of both thermal and wind forcing.
More suggestions(15)
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and good variation in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com