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The phrase "and large numbers of" is correct and usable in written English.
It can be used when referring to a significant quantity of people, items, or data in a context where you want to emphasize the scale.
Example: "The study revealed that large numbers of participants reported feeling more engaged in their work."
Alternatives: "and a significant amount of" or "and many individuals".
Exact(57)
Montgomery was killed, and large numbers of colonials were captured.
The army retaliated and large numbers of civilians were killed.
And large numbers of polluted Superfund sites remain unrepaired and dangerous.
About half of Palestinian youth are unemployed, and large numbers of children suffer from depression.
One, those with small Conservative majorities and large numbers of Indian voters.
They both have issues of overcrowding, and large numbers of minorities, with all those tensions.
And large numbers of pilots, flight attendants and ground staff are looking for work.
Millions of its citizens have suffered malnutrition and large numbers of refugees have fled into China.
This is because Ecuador's economy collapsed in 1999 and large numbers of migrants sought opportunities elsewhere.
Wildlife include seals and other marine mammals, and large numbers of birds nest along the coast.
Events are held throughout the year and large numbers of people visit as a result.
More suggestions(15)
and significant numbers of
and large concentrations of
and large volumes of
and substantial numbers of
and enormous numbers of
and huge numbers of
and vast numbers of
and large increases of
and large reductions of
and large models of
and large cadres of
and large colonies of
and large majorities of
and large vats of
and large teams of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com