TNBC, as a whole, has a poor prognosis and unlike ER+ and HER2+ tumours currently lacks targeted therapies, leaving systemic chemotherapy as the only adjuvant treatment option.
We now realize that there are at least 5 intrinsic subtypes within breast cancer, at least one of which the basal-like currently lacks targeted therapies and is the most pressing therapeutic challenge for the next decade.
This subgroup of patients currently lacks targeted therapeutic options.
The target ships proved impossible to decontaminate and, lacking targets, the test series had to be called off.
They were helped of course by the information policy of Lon Schattenberg [see above].' 'The testing strategy … was for the large part a routine operation (urine tests after the race, blood tests before the race in the morning) and frequently lacked targeting … This was the case even though practice had shown that when modifying the routine, riders would return positive results.
In the present study, several observations indicated that unlike highly conserved miRNAs, species-specific miRNAs are often weakly expressed, processed imprecisely and lack targets.
We might have missed some novel miRNAs that are specific to roses; however, these novel miRNAs are less likely to be important in functional studies because they are expressed at low levels and lack target-genes, whereas conserved miRNAs are usually highly expressed [ 23, 57].
In this context, the cohesin dyad-based hybrid-cellulosome [ 70] was free in the reaction solution and lacked the targeting function.
But the government's own aid watchdog gave their private sector aid spending an amber-red rating and warned that ministers lack targets and a clear focus on reducing poverty.
A cloud to cloud registration, based on the Iterative Closest Point (ICP) method [20] was also used for scans lacking targets and to improve the final registration by minimising the separation between overlapping point clouds.
