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However, ZNF496 variants were differentially expressed in bovine ovaries, and only the paternal variant was expressed in liver and kidney in a sheep family with polymorphic ZNF496 sequence.
Mitochondria play an important role in the development of malfunction of various organs, such as heart, liver, and kidney, in a mode that involves changes in turnovers of ATP, ROS, Ca2+, and release of proapoptotic proteins.
We have not yet electroporated both tissues (adrenal gland and kidney) in a single animal to see if there is an additive effect.
Pretreatment with the aqueous extract of Podophyllum hexandrum significantly ameliorated CCl4-induced depletion of GSH in both lung and kidney in a dose dependent manner.
Ginz and colleagues found altered organ morphology and considerable colloidal storage in parenchymal and reticuloendothelial cells of the liver, lung and kidney in a septic patient after synthetic colloid administration [ 2].
Moreover, Turski et al. (2009) reported that KYNA administered intragastrically in rats was absorbed from the intestine into the bloodstream and transported to liver and kidney in a time- and dose-dependent manner.
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This concern has been heightened since the occurrence of Wegeners Granulomatosis (an autoimmune vasculitis affecting the lungs and kidneys) in a subject who received a recombinant hepatitis B vaccine adjuvanted with ISS, an oligonucleotide similar to CPG 7909 [21].
6 Aldosterone is metabolised by 18β-glucuronidation in both the liver and kidneys in a reaction that is catalysed by the enzyme UDP-glucuronosyltransferase-2B7.
Allam et al. observed a greater expression and activation of mouse double minute 2 homolog (Mdm2) gene in the spleen and kidneys in a mouse model of lupus (MRL-Fas lpr mice) than healthy controls.
Fig. 2 Histopathological classification of gills, liver, and kidney in rainbow trout (a), barbel (b), loach (c), and European bullhead (d) from the investigated field sites on the Argen River.
Errβ suppresses glucocorticoid receptor activity in neuroblastoma and kidney cells in a dose-dependent manner, suggesting that it may also regulate metabolism at least in part through modulation of the hypothalamic-pituitary-adrenal (HPA) axis [ 22].
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