Sentence examples for and its abrogation from inspiring English sources

regulates the gene expression level, and its abrogation will uniformly alter the gene expression in the affected cells.

Gene expression profiles revealed that MMP-13 was among the up-regulated genes in tumour-bone interface and its abrogation reduced bone erosion.

Similar NET induction by ACPA-positive and -negative RA sera and its abrogation by IgG depletion, as discussed earlier, supports the functional aspect of the nucleosome measurement in RA serum.

Although this phenotype can depend on the cell type, some mutations affecting this state are observed in numerous cell types and reproduced by our model; for instance, the senescent arrest arises from overexpression of p16INK4a [ 4, 7] and its abrogation from p21 or p16INK4a inactivation [ 7].

This study shows the induction of apoptosis by serum deprivation, and its abrogation by glucocorticoids occurring in human mammary luminal epithelial cells transformed by expression of neu-T, and implicates the involvement of receptor protein tyrosine kinases in an apoptotic signalling pathway in this cell type.

VG76e is an anti-human VEGF mouse monoclonal antibody that has previously been shown to block VEGF activity, both by its inhibition of VEGF-dependent growth stimulation of human umbilical vein endothelial cells in vitro, and its abrogation of angiogenesis in the primate corpus luteum in vivo (Fraser et al, 2000).

It modulates cellular interaction with the ECM by its binding to structural matrix proteins, such as collagen and vitronectin, and by its abrogation of focal adhesions, which are features contributing to a counter-adhesive effect on cells.

Together, these observations suggest that clathrin may act as an integral component of the mitotic spindle apparatus and that its abrogation may lead to chromosomal instability and, ultimately, cancer [7] [9].

Importantly, it has been demonstrated that FXR activation results in a slight reduction of HDL and in an induction of LDL [ 27], and therefore its abrogation might also provide some explanation for the hypo-cholesterolemia observed in HIV-positive persons.

The UbcH10-expression pattern in cancer supports the notion that this regulatory axis controls cellular proliferation and that its abrogation leads to carcinogenesis.

However, a (pro- collagen typro- collagen typeapy remaInspecificultherapyts theremainsc abrogation may incur unwantedifficultfects.