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The 'excitotoxicity hypothesis' of neurodegeneration was first proposed in 1957 (Lucas and Newhouse, 1957) and it persists as a likely pathophysiological mechanism in HD.
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Despite much research directed at understanding and controlling breast cancer, it persists as a major health burden.
After an initial acute phase of illness, it persists as a chronic infection, primarily in the liver.
As the remnant low pressure meandered across the southwest United States it moved north, and tracked offshore of California, where it persisted as a remnant low and produced shower activity to parts of California.
The enduring whiteness of the American media has real consequences – and it persists even as a number of black journalists have become prominent, and even celebrated, figures in American journalism.
It persisted as a distinct tropical cyclone until later that day.
If the mound persists as a stubborn relic of winter, though, it also serves as a warning.
It will persist as long as human beings are alive.
First of all, obesity often persists as a result of individual choice.
Only the outer layer of the outer integument generally persists as a membranous seed coat.
An endocrine etiology for this problem persists as a popular but unproved theory.
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