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Very often, transcription networks are very complex, and it becomes difficult to understand the interaction between the transcription factors.
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When this occurs, it becomes difficult to understand who is dealing with which aspect of a fraud problem.
It has been pointed out that, in emergency situations, it often becomes difficult to understand or record clinical information[ 8- 10].
In effect it is a perceptual and mental "event horizon," beyond which the future becomes difficult to understand or predict.
The drawback of an augmentation based technique is that it may add up to | V|4 nodes, thus the drawing becomes difficult to understand.
Without rigorous software development and maintenance, software tends to lose its original architectural structure and become difficult to understand and modify.
But there is no more transparency anymore, and things have become difficult to understand.
As a result, discussion of the various historical states of this chromosome can become difficult to understand.
It becomes difficult to maintain faith.
It becomes difficult to move.
This meant that it became difficult to find data, or understand its utility or purpose.
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