Given the apparent association between depression and CVD, it appears plausible to assume a partly joint causal relationship.
And similarly, it appears plausible that while mechanisms of fibrosis are similar in individual patients, there may be differences which pathway is the causal driver in such patients.
And in further analogy, it appears plausible that the fibrosis in patients with interstitial nephritis and high eosionophiluria is more similar to the fibrosis in patients with idiopathic pulmonary fibrosis and high eosinophil count within bronchial fluid than to the fibrotic process in patients with hypertensive nephrosclerosis, particularly from a therapeutic point of view.
As beneficial effects of uricase and allopurinol were observed in terms of alveolar barrier dysfunction, it appears plausible that ASC and NLRP3 are involved in VILI via inflammation-independent mechanisms.
Given that yeast EndoG is physically and functionally connected to the PTP, it appears plausible that α-synuclein toxicity is exerted via opening of the PTP and subsequential translocation of mitochondrial EndoG to the nucleus, causing DNA fragmentation and death.
In summary, it appears plausible that efficient and rapid differentiation, as induced by araC and DAC, requires the concomitant proteolytic degradation of stem cell factors and PcG proteins.
Therefore, it appears plausible that xanthine and xanthine oxidants may contribute to vascular dysfunction in addition to, or in place of, uric acid in states of hyperuricemia and hypertension.
Biologically, it appears plausible for physical activity and lean body weight to decrease pancreatic cancer risk.
It appears plausible, for example, that physicians and medical students may be more bm- than bps-orientated.
Based on these data, it appears plausible that SCRiPs evolved linage-specific, and subsequently acquired similar, but different (sub-functionalization), or new (neo-functionalization) functions after gene-duplication events [20].
