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p300 is an acetyltransferase that becomes activated upon acetylation and is involved in the activation of transcription of a large number of genes (reviewed in Chen and Li).
Platelet-activating factor (PAF) is a bioactive phospholipid that accumulates during ischemia-reperfusion and is involved in the activation of platelets, neutrophils, and pro-inflammatory signaling.
In many tissues, TSP-1 is secreted by adult macrophages and monocytes upon wounding and is involved in the activation of transforming growth factor beta.
GRP78, also referred to as BiP, is a central regulator of ER homeostasis and is involved in the activation of the ER stress response.
Also cobalamin is a necessary cofactor in the Wood-Ljungdahl pathway, and is involved in the activation of several methylated compounds as well.
Elevated expression of HSP90 is a poor-prognosis factor and is involved in the activation of the Akt/mTOR pathway in UPS.
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TRIF is involved in the activation of NF-κB signaling and induction of type I IFNs86.
PKB is involved in the activation of S6K via an indirect activation of mTOR.
We next addressed whether Bi-VSP is involved in the activation of plasminogen.
These residues are involved in the activation of the enzyme (formation of compound I) by heterolytic cleavage of H2O2.
Superoxide or one of its derivatives may be involved in the activation of quiescent mitochondria.
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