Sentence examples for and is efficacious from inspiring English sources

Honigberg, L. A. et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.

Rapadocin is a potent, isoform-specific and FKBP-dependent inhibitor of the equilibrative nucleoside transporter 1 and is efficacious in an animal model of kidney ischaemia reperfusion injury.

Smith, B. D. et al. Altiratinib is a potent inhibitor of TRK kinases and is efficacious in TRK-fusion driven cancer models [abstract].

The compound shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain.

Compound 1 exhibits >7 fold induction of phosphorylated Histone H3 and is efficacious in an in vivo HT-29 tumor xenograft model.

Compound 11 has an IC50 of 200 nM and is efficacious in the Guinea-pig tracheal potential difference (TPD) model of ENaC blockade with an ED50 of 44 μg kg−1 at 1 h.

A variety of AXL inhibitors have been developed and are efficacious in preclinical studies.

The potent and selective RARγ antagonist LY2955303 demonstrated good pharmacokinetic properties and was efficacious in the MIA model of osteoarthritis-like joint pain.

The most promising compound displayed a good pharmacokinetic profile in multiple animal species, and was efficacious in an acute feeding study in rats.

The optimized formulation provided a constant ECN in situ release of 5 mg/h and was efficacious against selected Candida strains in vitro.

Artemisinin derivatives rapidly clear parasitemia and are efficacious in treating uncomplicated and severe knowlesi malaria.