The number of studies is rapidly expanding, and involve a spectrum of agents including COX2 inhibitors (Harris et al, 2000), HER1 and HER2 kinase inhibitors (Kurokawa and Arteaga, 2001), farnesyl transferase inhibitors (Johnston et al, 2003) and mTOR inhibitors (Mita et al, 2003).
These behavioral tasks were selected as they assess locomotive, balance, anxiety-related and social contextual behaviors in Mecp2-deficient mice that have relevance to co-morbidities seen clinically in Rett syndrome patients (17), and involve a spectrum of different neural circuitries.
Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins.
Acupuncture is a complex intervention that always involves a spectrum of treatment factors (pathologic-specific effects) and associated effects (placebo, non-specific, context effects), which makes it extremely difficult to fully unravel the inner mystery of this biological phenomenon [ 10].
The results of this study show that the risks of sub-optimization and maladaptation can be reduced by including many aspects in short- and long-term perspectives and involving a broad spectrum of stakeholders.
Third, authentic PPIs in vivo depend on specific biological contexts (e.g., tissue specificity, environmental conditions) and involve a wide spectrum of mechanisms.
The design and manufacturing of a chemical product and its process involve a spectrum of physical and chemical phenomena, over characteristic scales that cover many orders of magnitude, from molecular design at 0.1 nm to global warming at 104 km.
Productive pursuit of this topic has inescapably involved a spectrum of political, cultural, personal, and interpersonal factors that are normally not encountered in more conventional scientific scholarship, but have both enriched and complicated the enterprise in many ways.
To the best of our knowledge, this is the first case report involving a spectrum of abnormalities associated with poor prognosis in AML-M4 [E0].
As mentioned before, epigenetic regulation involves a diverse spectrum of molecular interactions in which both short and long non-coding RNAs play master regulatory roles.
