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Resveratol, a dietary polyphenol, downregulated expression of EMT master genes Zeb1, Snail and Slug and impaired CSC self-renewal capacity, tumor growth and invasion in a mouse model of pancreatic ductal adenocarcinoma [144].
We found that recombinant SFRP3 could inhibit Wnt5a signaling, and that it inhibited melanoma cell migration and invasion in a Wnt5a-dependent manner.
Addition of SFRP3 to melanoma cells had no effect on the number of viable cells, but decreased migration and invasion in a Wnt5a-dependent manner.
We are currently developing a 3D co-culture system in vivo to capture more representative features of the bone microenvironment, such as cellular migration and invasion in a 3D matrix and tumor-stromal cell interactions.
Taken together, loss of SPRY2 cooperates with EGF stimulation and enhances proliferation and invasion in a PTEN-dependent manner.
The loss of TGF β sensitivity in prostatic CAFs promoted PCa cell proliferation and invasion in a xenograft model [ 56].
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We showed that overexpression of miR-215 decreased cellular migration and invasion in an RCC cell line model.
The pro-inflammatory prostaglandins and leukotrienes directly induce epithelial tumor cell proliferation, survival, migration, and invasion in an autocrine and paracrine manner [ 3].
The tumor marker Fascin is an actin-bundling protein related to migration and invasion in an increasing number of neoplastic diseases [[ 28],[ 29],[ 41]].
This study showed that collagen protects progenitor cells from apoptosis and increases adhesion and invasion in an extracellular signal-regulated kinase pathway-dependent way [ 116].
In summary, our results suggest that subcurative radiation increases tumor cell proliferation, migration, and invasion in an rat model of primary human GBM.
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