It suppresses intestinal iron uptake and releases from internal stores by facilitating the degradation and internalization of the only known iron exporter, ferroportin (FPN), which is expressed on the surface of enterocytes, macrophages, and hepatocytes (Babitt and Lin, 2010).
Participants reported reductions in body checking and internalization of the thin ideal.
Flow cytometry and confocal microscopy results showed significant cellular uptake and internalization of the particles by cells.
Thus, GRKs are involved in desensitization and internalization of the D2 receptor in heterologous expression systems, but likely due to a scaffolding action or phosphorylation of proteins other than the D2 receptor.
Conjugation of rhBMP-2 inhibited the free lateral diffusion and internalization of the activated complex of rhBMP-2 and the bone morphogenetic protein receptor.
Internalization of societal standards of physical attractiveness (i.e., internalization of the thin ideal for women and internalization of the mesomorphic ideal for men) is a widely studied and robust risk factor for body dissatisfaction and maladaptive body change behaviors.
Using time lapse fluorescence imaging in living cells and other quantitative imaging approaches, it is found that heparan sulfate proteoglycans play a critical role in the attachment and internalization of the particles in alveolar type II epithelial cell line (C10), a potential target cell type bearing apical microvilli.
The protein kinase C inhibitor staurosporine prevented phosphorylation and internalization of the receptors by CXCR1 activation.
SCARB2 mediates binding of EV71 at the cell surface and internalization of the virus via a clathrin-dependent pathway.
