STATs are often involved in the regulation of complex promoters or enhancers that bind multiple transcription factors, where they can bind as tetramers (a process mediated by the amino terminus), and interact with additional transcription factors such as Jun, specificity protein 1 (Sp1), and the glucocorticoid receptor.
Furthermore, in the cell TRiC and htt (and mhtt) interact with additional partners, which would change the effective concentrations available for their interaction.
However, the degree of such expression appears to be unrelated to the likelihood of disease regression, raising questions as to whether receptor overexpression should be a prerequisite for cetuximab treatment and whether the drug interacts with additional molecular targets (Cunningham et al, 2004).
In addition to previously reported interactions with anionic lipids, phosphatidylserine (PS), phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5 P2], and phosphatidylinositol 3,4,5-trisphosphate [PtdIns 3,4,5 P3] , 11 Syt1 also interacts with additional phosphorylated phosphatidylinositides and other anionic lipids.
One attractive possibility is that F11-VK interacts with additional RhoGTPases that are also involved in regulation of cell-cell adhesion and cell migration.
The other possibility is that the MSL complex contains or interacts with additional general factors that would make the link to established regulatory chromatin transcription systems.
Although proteins binding to the P-rich region have not yet been identified, it is likely that this region interacts with additional components of the decay machinery, because in D. melanogaster the P-rich region was sufficient to trigger degradation of mRNAs in tethering assays (Haas et al, 2010).
However, it may also imply that CheY has additional functions and interacts with proteins other than those in chemotaxis pathways.
Extinction of conditioned fear is thought to occur through specific intra-amygdaloid circuitries involving, in particular, the LA/BLA and central amygdala interacting with additional intra- and extra-amygdaloid areas including, most importantly, the mPFC (e.g. Pare et al., 2004; Maren, 2005 Quirk et al., 2006; Sotres-Bayon et al., 2006; Herry et al., 2008).
Peptide binding to anionic heparan sulfate proteoglycans and chondroitin sulfate proteoglycans was involved in NRC-03 and NRC-07-mediated cytotoxicity; however, none of these molecules was exclusively necessary for target-cell death, suggesting that NRC-03 and NRC-07 interact with additional negatively-charged molecules on the surface of susceptible cells.
