A biomarker should be sensitive to low dose rate and, ideally, indicate low, medium, or high dose rate exposure with, e.g., changes in time-of-onset and intensity of response.
This is in line with the hypothesis that defence compounds are induced in resistant as well in susceptible interaction, the main difference being the speed and intensity of response.
Through their constellation of cell surface receptors, NK cells can detect variations in cell surface composition manifest through a multitude of ligands and integrate this information to determine the type and intensity of response that is appropriate [ 49].
These properties affect the timing and intensity of responses to hydrologic stresses such as precipitation, infiltration or pumping.
Furthermore, the analgesic and anti-inflammatory response obtained in experimental albino rats from in situ gelling emulgel (E4) showed significant improvement in both duration and intensity of responses compared to Piroxicam containing conventional in situ gelling formulation (E5) and suspension, without showing signs of significant gastric irritation.
Although susceptibility for presenting an adverse clinical course (i.e., sepsis, septic shock, multiples organ failure, or death) varies due to different degrees of inflammatory response [ 30], genetic factors of the host may influence the nature and intensity of this response.
The scale and intensity of public response have been impressive.
The scale, speed and intensity of the response were striking.
Joining the two men on a helicopter tour of the damage was W. Craig Fugate, the rumpled head of the Federal Emergency Management Administration, which has won unstinting praise from Mr. Christie, a Republican, for the speed and intensity of its response to the devastation.
As the Romney campaign was confronting questions about the candidate's position on the federal role in emergency response, Mr. Obama and Mr. Christie were being accompanied on their tour of a devastated New Jersey by FEMA's administrator, W. Craig Fugate, whose agency has won unstinting praise from Mr. Christie, a Republican, for the speed and intensity of its response to the devastation.
Therefore, it is tempting to speculate that high levels of circulating IFNγ in AKR/J mice may stimulate expression of Adcy7 in immune cells, with concomitant effects on intracellular cAMP levels and intensity of inflammatory response in these mice.
