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Consequently, to compare the predictive capability of our approach against other methods, we implemented prognostic models that differ in the way class-specific transcriptional association networks are inferred, and in the supervised classification methodology applied on the network information.
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Five patients in the radial extracorporeal shockwave group and two in the supervised exercise group claimed for disability pension.
In total, 411 participants were recruited within 14 months, 247 participants in the start-up and 164 in the supervised program, with 2 to 30 subjects per HCC.
2 Twenty-one studies were included (16 in high-resource countries and five in resource-limited settings), giving an overall sample size of 7,512 participants in the unsupervised arm and 4,890 in the supervised arm.
Second, a new semi-supervised Fuzzy C-Means (S-FCM) algorithm is designed using pre-computed cluster number and cluster centers in the supervised pattern discovery stage.
The cohort included 76 patients in the control group and 389 patients in the supervised group.
Seventeen (33%) patients in the radial extracorporeal shockwave group and 12 (23%) in the supervised exercise group were on sick leave because of shoulder pain.
Such an apparent overestimation of positive regulatory relationships was due to the fact that similar numbers of positive and negative examples in the supervised learning stage.
Thirteen patients in the radial extracorporeal shockwave group and three patients in the supervised exercise group received additional treatment (cortisone injections, chiropractic treatment, physical therapy/supervised exercises) between 12 and 18 weeks (odds ratio 5.5, 95% confidence interval 1.3 to 26.4; P=0.014).
Based on the HCP records of each participant and personal communication between participants and researchers, 51 (20.6%) in the supervised program did not complete the planned full year and 38 (23.2%) in the start-up program (based on data of 10 start-up and 15 supervised HCCs and all registrations by researchers).
MBG participated in the supervised and the homogeneity analysis and helped to draft the manuscript.
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