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The results suggest that the migration/recruitment of monocytes and fibrocytes into fibrotic tissues, mediated at least in part by CCR1, CCR2, and CCR3, plays a major role in the progression of lung and skin fibrosis and in the predisposition of AA to fibrotic diseases.
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This also reflects the role of genetic and epigenetic modifications at important genes such as BRCA1 and BRCA2 in the predisposition to the disease [ 30].
Figure 1 illustrates the regional flow differences (Fig. 1a,b) and wall shear stresses (Fig. 1c) in the AA and DT and the predisposition of AA to atherosclerosis (Fig. 1d).
The current finding of an area and lamina mismatch between the input sites from the amygdala and hippocampus is, therefore, relevant as it supports and informs those models that seek to distinguish hippocampal and amygdala interactions within prefrontal cortex in the predisposition and maintenance of PTSD (Admon et al. 2013).
These data suggest that the rs2498794 polymorphism of the AKT1 gene is associated with a long smoking duration and may be involved in the predisposition to cancer when the smoking duration is short or the cigarettes per day is rate low.
3. Political: Several political determinants act in concert in the predisposition and perpetuation of accident and injuries in Nigeria a) Lack of adequate legislation, regulations and proper enforcement on speed limits, seat belts, crash helmets and domestic and civil violence.
Germline mutations of the tumour suppressor gene BRCA1 are involved in the predisposition and development of breast cancer and account for 20 45% of all hereditary cases.
The TPH2 gene and its 5' upstream region variants (SNPs: rs4448731 and rs4641527) may be involved in the predisposition to suicide in MDD [ 14].
This replication suggested further exploration of this SNP and its related functional variants in the predisposition to ADHD.
MelGene serves as a comprehensive reference repository for genetic association data in CM and can provide further insights in the predisposition of CM by systems biology approaches.
These findings provide evidence that the Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of AF.
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