However, the uncertainty in the odd-numbered β parameters, and therefore in the inferred quit rates, is taken into account.
This kind of difference in behaviour is captured as part of our analysis and reflected in the inferred parameter variances (see Figure S13 in Additional file 1).
From each dataset, we also observed the enrichment of the binding sites of CTCF, Pol II and Taf1 in the inferred cluster boundaries (Additional file 1: Figure S 11A, Additional file 1: S 11B).
If x operations are applied to leaf i to yield leaf i ′ and y operations are applied to leaf j to yield leaf j ′ (where leaves i and j are in the inferred tree and leaves i ′ and j ′ in the bootstrap), the expected distance between i ′ and j ′ is increased by (x + y) compared to the distance between i and j.
Table 1 lists the prior connections and the connections in the inferred ODE network and Markov network which were consistent with the prior connections.
We made biological interpretations for drug side effects and protein domains in the inferred pharmacogenomic features.
It operates by maximising Hardy-Weinberg Equilibrium and linkage equilibrium in the inferred clusters.
The difference between robust and brittle populations in the inferred number of haplotypes was found to be statistically significant (two-tailed t-test: P0.05,4 = 0.007).
Moreover, FOXA1, an effector of PPAR γ (Varley et al., 2008) and a co-factor of GATA3 in luminal breast cancer (Kong et al., 2011), is a significant co-regulator of both GATA3 and PPAR γ in the inferred network.
We specifically address the problems of sampling the prior (which arises in a complex form in nested sampling [ 16, 19]), defining and exploring the prior volume, and experimentally quantify the uncertainty in the inferred parameter means and standard deviations for a circadian model that is representative of the single feedback loop topology.
