Sentence examples for and in the checkpoint from inspiring English sources

Basically, a drill to freeze the checkpoint means that movement through and in the checkpoint stops.

These results demonstrate the general importance of checkpoint regulation of G1/S transcription in response to replicative stress and elucidate the specific roles of Mik1 and Mrc1 in the checkpoint.

These two KEN boxes are conserved from yeast MAD3 to human BUBR1 and are required for the concerted action of MAD3 and MAD2 in the checkpoint inhibition of CDC20-APC/C [15] [17].

We show that Aurora B and Mps1 strongly synergize in the checkpoint.

Finally, CHD4 depletion leads to defects in the G1 to S transition, probably by controlling deacetylation of p53, and in the G2/M checkpoint upon DNA damage [ 128- 130].

Both yeasts have a TTK member, which is known to play roles both in spindle pole duplication and in the spindle checkpoint response that monitors attachment of chromosomes to the mitotic spindle [ 81].

The CDC25 phosphatases are key regulators of cell cycle progression and play a central role in the checkpoint response to DNA damage.

Both rad1+ and rad3+ function upstream of chk1+ in the checkpoint response pathway.

If Bub1 and Mad1 have an additional role in the checkpoint, unrelated to Mad1 kinetochore localization, it should be possible to identify separation-of-function mutants that preserve kinetochore localization but are deficient in checkpoint signalling.

This is consistent with the functional interdependence of ULK3 and CHMP4C in the abscission checkpoint and could contribute to creating a feedback loop that sustains the inhibitory signal.

The DNA mismatch repair (MMR) pathway is essential in maintaining genomic stability through its role in DNA repair and the checkpoint response.