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Daussy, C. et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow.
In patients with cancer, disseminated cancer cells are often detectable in the peripheral blood as circulating tumour cells (CTCs) and in the bone marrow or lymph nodes as disseminated tumour cells (DTCs).
The standard model of mammalian B-cell development holds that B cells arise from haematopoietic stem cells (which can give rise to all types of blood cell), in the liver during fetal life and in the bone marrow after birth.
Disease may be extensive and metastatic (spreading to other areas of the body) at diagnosis, with cancerous cells typically found throughout the bones and in the bone marrow.
For example, the rapidly dividing cells in the skin, in the mucosal lining of the oral pharynx (the region that forms the back of the mouth cavity and upper part of the throat) and the gastrointestinal tract, and in the bone marrow are susceptible to immediate, though temporary, damage as a result of radiation therapy.
CLL cells proliferate in pseudofollicles in secondary lymphoid organs and in the bone marrow, where they receive support from the microenvironment.
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They develop from hematopoietic stem cells and mature in the bone marrow and the liver.
Together, these studies indicate that remodeling enzymes such as MMP-9 and others play a crucial role in vasculogenesis at both the injury site and in the bone-marrow where quiescent EPCs reside.
The likelihood of important direct effects of estrogens on bone is based on the presence of ERα in the bone-forming osteoblasts [ 64, 65, 66] and in the bone-resorbing osteoclasts [ 67].
Miura et al. described diffuse bilateral FDG uptake in the lungs, in the bilateral renal cortex and in the bones in 4 consecutive patients.
The kinetics of promonocytes and monocytes in the bone marrow.
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