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Plasmin is able to cleave a variety of proteins of the extracellular matrix (ECM) such as collagen type IV, laminin, fibronectin and vitronectin and is also involved in the conversion of some matrix-metalloproteinases from the zymogen pro-form into active enzymes and in the activation of latent TGFβ or in the release of bFGF from ECM-binding sites.
Moreover, it has been shown that rather than acting solely as a tumour suppressor, SMARCA4 is involved in senescence and in the activation of p53 (Ref. 69).
Here, we show that activation of three different KNOXI proteins using an inducible system resulted in a rapid increase in mRNA levels of the cytokinin biosynthesis gene isopentenyl transferase 7 (andPT7) and in the activation of ARR5, a cytokinin response factor.
The most relevant differences emerged in the deactivation of both posterior cingulate cortex (PCC) and bilateral angular gyrus (AG) and in the activation of the anterior cingulate cortex (ACC).
Wnt has been proposed as an important player in the development of effector T-cells and in the activation of the regulatory T-cell [38].
Besides, they are also involved in stimulation of cytokine production, proliferation of human T lymphocytes and in the activation of protein kinases [32].
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Nutrient depletion limits growth and proliferation and culminates in the activation of stress response genes.
This indicates that SNTA1 and P66shc cooperate and function in the activation of the Rho GTPase Rac1.
Ser216 lies on the active site and functions in the activation of Cys215[43].
Overall, all the inhibitors tested showed significant inhibitory effect on PR activity and resulted in the activation of eGFP expression in our SupT1 clone.
Thereby, new information about pathophysiological mechanisms can be gained and differences in the activation of human and animal cells detected.
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