"In specific instances, this could be a practical approach," says virologist Albert Kapikian of the National Institute of Allergy and Infectious Diseases.
Despite the lack of a genome-wide increase in burden of potential fusion-gene generating CNVs in ASD, specific instances could still be of potential significance.
Notably, a single instance could be identified.
For instance, specific behaviours could be governed by independent, functionally distinct modules.
In the first instance, the patients could have been wrongly deemed eligible, or ineligible, and in the second instance, patients with specific characteristics could be systematically refusing to participate or dropping out, or conversely, patients with specific characteristics could be systematically agreeing to participate.
In such instances, it could be difficult to identify the specific combination of genes whose loss causes the phenotype.
In the first instance, specific dose response curves could be estimated, whereas in the latter case, specific parameter estimates were obtained by carefully choosing the populations or breeding sites to be included in the analysis.
In certain instances, industry-specific calculators could be required.
In some instances, this could be a plus.
Specific waivers could be obtained in some instances.
Hate speech may still need to be banned in specific instances, I would argue.
