In some cases, problematic body weight is not (or not primarily) the result of one's behaviour, but a largely inescapable outcome of a genetic constitution, a medical condition, or a medication regime.
Beyond the laughter, though, "Up the Down Staircase" touched on a variety of social issues that were beginning to affect schools and, in some cases, remain problematic today: poverty, racial strife, drug addiction, crime, teen pregnancy and even the sexual tension between students and teachers.
However, the design of an optimal synthesis route can be an arduous and fickle task due to the large number of theoretically possible, and in many cases problematic, synthetic strategies.
In view of the fact that experiments are often time-consuming and, in some cases, meteorologically both problematic and expensive, intensive work has been done over the past few years on the development of mathematical approaches and procedures to evaluate real thermal and moisture transfer processes.
Note that this step is not obligatory and in some cases can be problematic since the steady state equations have to be solved.
For example, extrinsic labelling of proteins can, in some cases, be problematic, requiring protein engineering to provide a suitable residue to which fluorescent dyes can be covalently coupled and it can be time-consuming to separate labelled and unlabelled proteins.
However, using an out-cross for the purpose of genetic mapping can in some cases be problematic, as it could introduce phenotypic variability due to the generation of a heterogeneous genetic background.
This makes the applicability of this theorem – and hence the defense of market solutions in such cases – problematic.
However, in some cases this seems problematic.
However, in some cases, identification is problematic at the generic as well as the specific level.
