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Performance in a short-term spatial working memory task was enhanced by lactate injection, and impaired in a dose-dependent manner by inhibitors of glycogenolysis or lactate transport.
These results are consistent with another study showing that GFP-Opi1p translocation into the nucleus is slow and impaired in a pis1 partial function mutant (Loewen et al. 2004).
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In contrast, the DNA damage checkpoint requires ATM and was impaired in A-T cells.
The clearance time was found to be impaired in groups A and B including children of 4 7 and 8 11 years of age respectively.
CO2 reactivity was globally impaired in one patient and impaired in one hemisphere in one patient.
S-phase delay, however, was almost exclusively restricted to sensitive cells and was impaired in a model of treatment-induced resistance.
Put simply, we postulate that CNS cells will display a senescent phenotype that is physiologically similar to cells that have undergone replicative senescence, and be functionally impaired in a way that leads to neuronal dysfunction and degeneration.
Supporting this work, we previously found that levels of Rab11 were significantly decreased and endocytic recycling was impaired in a cell and mouse model of HD further connecting alterations in the Rab11 function with impaired vesicle formation (15).
In addition, auditory verbal learning and delayed recall was impaired in a group of 9- and a group of 16-year-old children with moderate NE [ 31, 47].
Indeed, flagella and chemotaxis gene expression but not growth and cell division are impaired in a ctrA knock-out mutant of Rhodobacter capsulatus[ 20, 21].
These data indicate that condensin binding and mitotic chromosome condensation are impaired in a cut3-477 genetic background at 25° and 32°, although the cut3-477 mutant strain is alive at these temperatures.
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