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Insufficient power also likely affected our ability to detect differences with time to event analyses and global tests of effect.
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The entire procedure of filtration and global testing of p-values are summarized in Table 2.
Analysis was done using a genotypic model, i.e. the three genotypic classes possible for each of the phenotypes were treated as a separate class each and global test on equality of the three means was performed.
For example, many repeated observations when there is a chance of clustering could lead to spurious significance for the local and global tests for clustering of residential histories.
Although omnibus tests of parameter equivalence reduce Type I errors by decreasing the number of statistical tests when the null hypothesis is true, Bontempo and Hofer [ 24] have suggested that perfectly invariant factors can obscure noninvariant factors and make multivariate global tests of invariance misleading.
With the goal of identifying allelic variants that significantly contribute to pathogenesis and smoking-related traits, global tests of associations were performed between each SNP of the AKT1 gene and cancer predisposition and smoking behaviors.
In the initial unweighted (complete case) analysis at 20 weeks, global tests of equality and contrasts showed between group differences in fatigue (F2268=4.49; P=0.012), physical functioning (F2267=5.36; P=0.005), depression (F2268=5.03; P=0.007), and sleep (F2266=5.99; P=0.003).
Major or fatal bleeding in the ICU is thought to be associated with prolonged global tests of coagulation and low platelet counts rather than with the use of prophylactic anticoagulants or antiplatelet agents [ 22].
We used global tests of main effects and treatment interactions, adjusting the P-values for multiple correlated tests.
For the global tests of repeated measures analysis of variance and CMH, significance was defined as P<0.05.
Global tests of association were significant for BRAF (P=0.005) and ERBB2 (P=0.034).
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