Insufficient power also likely affected our ability to detect differences with time to event analyses and global tests of effect.
Analysis was done using a genotypic model, i.e. the three genotypic classes possible for each of the phenotypes were treated as a separate class each and global test on equality of the three means was performed.
For example, many repeated observations when there is a chance of clustering could lead to spurious significance for the local and global tests for clustering of residential histories.
GO BP term enrichment tests were carried out using the GOHyperG function of the GOStats library from Bioconductor [30] and the global testing of genes grouped by KEGG pathway was done using Bioconductor's globaltest package [34].
To circumvent this limitation, we incorporated global testing of p-values and ReliefF algorithm using the method proposed in Section Combined global testing and filtration technique.
Therefore, in the context of MCs of treatments versus control, the nonparametric Simes test is validated for the global testing of the intersection hypothesis.
Global testing of the transcriptome with a particular variable (e.g., seed development stage) was carried out using the Globaltest package [ 51].
This method allows adjustment for covariates (age, sex, BMI, diabetes duration, current smoking, hypertension, HbA1c, triglyceride, HDL cholesterol, LDL cholesterol) and provides a global test of association, as well as haplotype-specific tests.
Although omnibus tests of parameter equivalence reduce Type I errors by decreasing the number of statistical tests when the null hypothesis is true, Bontempo and Hofer [ 24] have suggested that perfectly invariant factors can obscure noninvariant factors and make multivariate global tests of invariance misleading.
For comparison between children with Hib, capsulated non-b and uncapsulated infections, a global test of difference was performed.
