Of these, two induce a pronounced widening of vessel diameter without a substantial loss of vessel number, one compound produces a loss of retinal blood vessels accompanied by a mild increase of their diameter, and finally one other generates a severe loss of retinal vessels.
If certain conditions are met (Sepsis-screening tool alert parameters), the system generates a "severe sepsis and septic shock" alert, and the test is considered to be positive.
Since enzymatic reactions are sensitive to temperature, but light capture is not, this stress combination generates a severe imbalance between mechanisms' high energy absorption and low energy use through enzymatic carbon assimilation (Ball et al. 1991).
By producing O-methyl adducts, MNNG generates a severe damage in DNA that provokes the activation of nuclear repair proteins, such as PARP-1.
The lower fitness of homozygous individuals than of heterozygotes nonetheless generates a severe genetic load, leading to a "diploid male vortex", with a decrease in population size resulting in a decrease in heterozygosity at the csd gene, an increase in the proportion of diploid males, a decrease in population growth rate, and, if severe enough, a further decrease in population size [ 32].
TNF-knockout mice are more susceptible to bacterial infection and generate a more severe colitis than control mice (Naito et al., 2003; Xu et al., 2007).
In China, the marked imbalance of economic development has affected access to and use of maternal and child health (MCH) services, generating a severe inequity among various economic statuses.
Based on the mutation type, the combinatorial effects of two mutations or of one mutation with the wild-type protein can set the course of the disease and generate a mild to severe gradient of symptoms.
We hypothesized that, if an interaction between these pathways were critical, loss of both should generate a severe, synthetic phenotype and cause an abnormal circadian behavior.
The fault is notorious because, when combined with a fracture to the north, the Rodgers Creek Fault, the 100-mile system is estimated to have a one-in-three chance of generating a severe earthquake within the next 30 years, an estimate scientists say remains in force even if the northern segment of the Hayward Fault is creeping.
