Sentence examples for and gain expression of from inspiring English sources

Concomitantly, these cells lose expression of visceral endoderm markers and gain expression of markers for the definitive endoderm.

After exposure to each of 8 different ligands that activate TLRs 2, 3, 4, 5, 7, 8, and 9, CD8+ T cells are activated and gain expression of the C type lectin CD69 that may promote their retention in lymphoid tissues.

In contrast with most carcinomas that lose epithelial characteristics with tumour progression, EOCs undergo a mesenchymal epithelial transition, acquire a more differentiated phenotype and gain expression of E-cadherin (reviewed in [ 11]).

It has also been reported that postselection cells lose the expression of p16INK4a, a cyclin-dependent kinase (CDK) inhibitor [ 24, 25], and gain expression of cyclo-oxygenase (COX -2, a gene that is thought to be involved in tumorigenesis [ 28].

We found that airway epithelial cells gradually lost expression of junction proteins and gained expression of mesenchymal proteins, indicative of EMT.

Transforming growth factor beta-1 (TGF-β1) levels increased in mouse airways while epithelial cells lost expression of E-cadherin and occludin and gained expression of the mesenchymal proteins vimentin, alpha-smooth muscle actin (α-SMA) and pro-collagen I.

For example, mouse ES cells are capable of switching reversibly between Nanog positive and negative states, losing and gaining expression of a gene previously proposed as a key regulator of pluripotency [16].

Epithelial-to-mesenchymal transition (EMT) is an important mechanism during development and cancer progression whereby epithelial cells gain the capacity to migrate out of their context through down-regulation of epithelial markers, such as junction proteins and cytokeratins, and gained expression of mesenchymal proteins, such as vimentin and α-SMA [4], [5].

The same large differences remained at 24 months post-diagnosis, as it was evident that almost all CMV-specific cells had lost expression of CD27, CD28 and CD62L and gained expression of CD95, perforin and granzyme A, indicating that they were mature differentiated cells with the potential to kill virus infected cells [32], [35], [38].

These cells lost expression of E-cadherin and gained expression of vimentin.

Tumor cells often de-differentiate or have their origin in immature cell types and loose expression of proteins associated with highly differentiated cells, and could in stead gain expression of embryonic proteins.