Accordingly, we postulate that one of the mechanisms by which miR-519 suppress tumor growth is by inducing senescence, and further propose that miR-519 triggers senescence -at least in part- by reducing HuR levels.
The authors speculate that the gas exchange response may be a useful predictor of the utility of HFOV in the difficult-to-oxygenate patient and further propose that failure to demonstrate improved oxygenation after a 6-hour trial of HFOV should prompt a consideration of alternative rescue modalities such as extracorporeal life support.
This commentary on the special issue suggests that traditional media, such as film and television, may also meet some emotional needs and further proposes that the concept of presence (the subjective sense of 'being there' in a mediated environment) has some explanatory power when considering emotional responses to media.
Furthermore, LOI values increased firstly and then decreased with the content of DMTMI increased, which was related to the existence of rDA reaction, and further proposed that a competitive relationship between the release of inflammable cyclopentadiene during rDA reaction and cross-linking behavior occurred in combustion.
Academic Xavier Mendik also defines cult films as opposing the mainstream and further proposes that films can become cult by virtue of their genre or content, especially if it is transgressive.
For example, the group of Bruce Howard suggested the existence of cellular checkpoint mechanisms that monitor the proper maintenance of heterochromatin domains during cell proliferation, and further proposed that defects in their maintenance could contribute to the phenomenon of replicative senescence (Howard, 1996; Ogryzko et al., 1996).
Assuming that GLI1 might be involved into human breast cancer development and further proposing that GLI1 is activated through upstream members of the Hh signalling cascade, the mentioned Hh inhibitors could offer new drugs in the treatment of breast cancer as well.
They further proposed that sense of belonging is important for persistence in college, particularly for Latino students.
Garlid and colleagues further propose that during reperfusion, keeping the mitochondrial KATP channel open maintains the VDAC, CrK, ANT complex which is vital to export ATP rapidly from the mitochondria to the cytosol where it is used to drive contraction.
Within the context of history and culture, we further propose that psychosocial stress may partially explain the variable incidence of prostate cancer between these diverse groups.
We further propose that SMG1 and NIK are regulators for the metabolism of FLICE inhibitory protein (c-FLIP), a caspase-8 inhibitor.
