Sentence examples for and further activation of from inspiring English sources

The cause of HPS has been supposed to be hyper-activation of macrophages, T cells, and natural killer (NK) cells, hypercytokinemia caused by these activated cells, and further activation of these cells, that is, a malignant loop of excess cell activation and cytokine production [ 2, 4, 5].

These observations indicated that ectopic PAP1 overexpression by itself did not fully activate all rate limiting steps of anthocyanin biosynthesis, and further activation of the phenylpropanoid pathway required additional environmental signals.

Additionally, given the strong expression of TRAF2 in the raft microdomain of NOD Th40 cells (Figure 4), the possibility for interaction of induced cFLIPp43 with TRAF2 and further activation of Nf-κB, as has been demonstrated [34], arises.

DISC formation enables the autocatalytic cleavage and further activation of procaspases, thus triggering the death-executing cascade.

The latter will then result in caspase 3 activation and further activation of PKC- δ by caspase-3-mediated proteolysis.

However, the resistance mediated by Pto AvrPto interaction and further activation of HR is dependent on the nucleotide-binding site-leucine rich repeat protein Prf.

At this stage, the effort is focused on the elevation of BiP, assisting protein folding and preventing further activation of the UPR.

Our findings suggest that the physiological activation of mTORC2 may be required for proper skin wound healing and that further activation of other members of the mTORC2 signaling pathway may also be a viable strategy to influence skin recovery.

A study from our group has identified binding of TLX on the Oct-4 promoter in neural progenitor cells upon hypoxia, leading to self-renewal of these cells and a further activation of Akt signaling pathways.

There are at least three separate neuroendocrine axes involved in the pubertal cascade; adrenarche, the activation of adrenal androgen production; gonadarche, the activation of the gonads proper, and the further activation of the growth hormone-insulin-like-growth factor (IGF) axis that occurs at puberty.

Systemic administration of AT resulted in supraphysiologic levels of BALF AT levels (25.4 ± 4.9 vs. 5.3 ± 1.0 IU/ml) and prevented further activation of coagulation by MV (TATc, in LI-MV with AT vs. placebo, 3.9 ± 0.3 vs. 6.5 ± 0.8 ng/ml - P < 0.05).