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The histone code hypothesis, originally proposed a decade ago [ 1], suggests that specific combinations of histone post-translational modifications (PTMs) constitute an epigenetic marking system that determines distinct transcriptional and functional outputs of eukaryotic genomes.
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Toward clinical translation, it is critical that we understand how different biochemical, biophysical and biomaterial parameters of tissue culture govern the maturation and functional output of engineered myocardium, particularly when using pluripotent stem cell-based approaches.
It is widely accepted that the installation, maintenance and functional output of epigenetic modifications occur in concert via combinatorial sets of modifications.
For example, assays that exclusively evaluate the cytotoxic effects of Aβ species largely ignore subtle changes that have been shown to occur in the metabolism and functional output of neuronal cells prior to overt cell death (reviewed in [ 78]).
We present a new Neumann subproblem a posteriori finite-element procedure for the efficient calculation of rigorous, constant-free, sharp lower and upper bounds for linear and nonlinear functional outputs of the incompressible Navier Stokes equations.
An error estimation and grid adaptive strategy is presented for estimating and reducing simulation errors in functional outputs of partial differential equations.
Given this premise, a clear cut discordance between the functional outputs of Pmar1 and Hbox12 was expected.
In this paper we shall focus on the case of linear functional outputs of affinely parametrized linear elliptic and parabolic coercive partial differential equations.
Given that PERK-eIF2α signaling can result in inhibition of proliferation or induction of apoptosis we explored these two possibilities as functional outputs of this pathway in vitro and in vivo.
Collectively, these data demonstrate the role of the fast-acting glutamatergic synapse in the regulation of AgRP neuronal activity and functional output over long periods of time.
An anisotropic, unstructured grid adaptive method is presented for improving the accuracy of functional outputs of viscous, compressible flow simulations for general discretizations.
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