Exact(1)
Frank Eisenhaber, Institute of Molecular Pathology, Vienna, Austria The work by Burroughs et al. is a careful, virtually encyclopedically complete collection of β-GF protein segments in sequence databases and a meticulous analysis of the associated structural and functional knowledge in the literature.
Similar(59)
Later advancements in gene annotations captured by the GCI scoring model, therefore, were defined by deeper levels of functional characterization, especially in the form of scientific publications describing individual genes and curated functional knowledge in databases such as KEGG, OMIM and SwissProt.
The power of integrative analyses utilizing genomics data and functional knowledge has been demonstrated in the analysis of individual datasets [ 16] and systematic efforts to expand our understanding of gene functions [ 17- 20].
In addition, intertwined with this is the level of genetic and functional knowledge that exists for the organisms exploited in the studies ranging from the so-called model organism (such as mouse and zebrafish) to those genetically underrepresented taxa where the small amount of genome information is overshadowed by the ignorance of their functional biology.
Technical and functional knowledge are vital to making good judgment calls, being legitimate in the eyes of your people, and making resource allocation decisions.
In most positions, whether it's enterprise sales, brand marketing, supply chain logistics, or corporate finance, being competent often consists of having deep functional knowledge in four or five key job areas and a good working knowledge in another four or five.
They tend to have both functional knowledge in a specific area as well as broad exposure across functions.
We consider this approach more trustworthy to obtain a reliable picture of functional knowledge in EDs.
Gene ontology annotations have proved to be one of the most frequently utilized sources of gene functional knowledge in computational biology, with numerous applications taking advantage of this structured and highly curated resource.
By providing current functional knowledge in a format that can be exploited by high-throughput technologies, the GOC provides a major freely available public annotation resource that can help bridge the gap between data collation and data analysis [1] (www.geneontology.org).org
Genome-wide screening is an 'agnostic' approach that is not limited by current biological functional knowledge used in the candidate gene approach, with the prospect of providing novel insights into the disease process.
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