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To understand how the essential ring-shaped chaperonin TRiC/CCT cooperates with the chaperone prefoldin/GIMc (PFD), we integrate cryoelectron microscopy (cryo-EM), crosslinking-mass-spectrometry and biochemical and cellular approaches to elucidate the structural and functional interplay between TRiC/CCT and PFD.
To extend our earlier studies [16], we sought to probe the molecular and functional interplay between Stat3, EGFR and Src and the underlying mechanisms of support of the pancreatic cancer phenotype.
This may be caused by various mechanisms of expression regulation and functional interplay between these factors under physiological conditions [ 11].
A comprehensive model for the mode of action of FACT at transcribed genes requires an understanding of the physical and functional interplay between FACT and histones in vivo.
In practice, the regulatory relationships behind many phenotypes are determined by complex and highly interconnected networks of physical and functional interplay between a multitude of pathway components [ 16].
MDR1/PgP acts as a glycolipid translocase involved in the biosynthesis of glycolipids such as Gb3, and elevated levels of Gb3 have also been seen in drug-resistant cancers, and functional interplay between membrane Gb3 and MDR1/PgP has been suggested (Lingwood et al, 1998; De Rosa et al, 2008).
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The observed variability in response to different probes of KCNMA1 might be explained by target specificity, and the functional interplay between these and other genes in the cell lines studied.
Continued identification and characterization of functional interplay between PARPs and RNA may provide important insights into the role of PARPs in RNA regulation.
This approach might unmask new biological functions and even define the functional interplay between metabolic pathways and the regulation of gene expression mediated by these ATs.
These results demonstrate a function of USP13 in ERAD downstream of retrotranslocation and suggest a potential functional interplay between USP13 and Bag6 that is required to maintain retrotranslocated substrates in a soluble and degradable state.
Here we review studies describing the time course of operation of parallel intracortical circuits and cortico-cortical connections between the PMd, PMv, PPC and M1, thus demonstrating that functional interplay between these areas and the primary motor cortices is not fixed, but can change in a highly task-, condition- and time-dependent manner.
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