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Such preferences, or kinetic motifs, encapsulate the possible roles and functional constraints of kinetic parameters.
To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chromatin interactions in human cells.
Many of these genes encoded neuropeptides, transmembrane receptors, and gated ion-channels that evolve under structural and functional constraints of ligand-receptor specificity and transmembrane localization [ 90].
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This study reveals likely structural and functional constraints on the genomic evolution of insect TipE gene family members maintained in synteny over hundreds of millions of years of evolution.
Taken together, these data agree with the conservation and functional constraint of PPARα toward evolution (Fig 1 and Additional file 3: Fig S3).
The insert does not show significant similarity to any known gene, precluding the inference of function and functional constraints by sequence similarity.
ITS sequences evolve rapidly, but size and functional constraints permit comparison of homologous sequences between taxa in genus or subgenus [14].
Strong evolutionary and functional constraints limit the expansion of microsatellite repeats in expressed regions of the genome [ 45, 46], because longer repeats have higher mutation rates and could therefore be less stable [ 47, 48].
Correlations observed at this broader scale are presumably the outcome of drift and selection as population sizes and functional constraints fluctuate over millions of generations [ 37].
Both developmental and functional constraints limit the range of observed changes in morphology, and these limits may require more complex models than were implemented here.
Functional rule is to determine the basic structure based on support, installation, auxiliary operation and other functional constraints of the part.
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